Reversing aging effects in the brain to improve cognitive function
Epigenetic Reprogramming to Counteract Neuronal Aging and Degeneration
['FUNDING_OTHER'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11017034
This study is looking at how changes in our genes might affect memory and thinking as we get older, especially in people with Alzheimer's, and it hopes to find ways to help brain cells regain their youthful abilities, which could lead to new treatments for cognitive decline.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11017034 on ClinicalTrials.gov |
What this research studies
This research investigates how epigenetic changes contribute to cognitive decline and dementia, particularly in Alzheimer's disease. By exploring the potential of reprogramming neurons using specific factors, the study aims to restore youthful characteristics to aging brain cells. The approach involves manipulating the epigenome to enhance neuroplasticity and potentially reverse cognitive impairments associated with aging. Patients may benefit from insights into new therapeutic strategies that target the underlying mechanisms of neuronal aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing cognitive decline or are at risk for Alzheimer's disease.
Not a fit: Patients with cognitive impairments not related to aging or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve cognitive function and quality of life for individuals experiencing age-related cognitive decline.
How similar studies have performed: Previous research has shown promise in using epigenetic reprogramming to rejuvenate neurons, indicating that this approach may be viable for addressing cognitive decline.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TIAN, XIAO — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: TIAN, XIAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease