Reversing age-related changes in retinal cells affected by glaucoma
Official title: In vivo epigenetic reprogramming of retinal ganglion cells in aging mice with glaucoma
Funded at Schepens Eye Research Institute · NIH-11026594 · Data updated 2026-11-12
This study looks at how getting older affects certain eye cells in mice with glaucoma, hoping to find new ways to protect these cells and improve treatments for people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Schepens Eye Research Institute NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $679,159 |
| NIH project number | 1R01EY036910-01 |
| Project ID | NIH-11026594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing glaucoma or those at risk due to age-related factors.
✕Less likely to help
Patients with glaucoma who are not affected by age-related changes or those with other unrelated eye conditions may not benefit from this research.
What this research studies
This research investigates how aging affects retinal ganglion cells (RGCs) in mice with glaucoma, focusing on the epigenetic changes that make these cells more vulnerable to damage. By studying the mechanisms behind RGC injury and aging, the researchers aim to identify new therapeutic targets that could protect and rejuvenate these cells. The approach involves using animal models to explore the relationship between elevated intraocular pressure and age-related susceptibility, potentially leading to innovative treatments for glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that directly protect retinal cells from damage caused by glaucoma, improving vision preservation for patients.
How similar studies have gone: Previous research has shown promising results in understanding the epigenetic mechanisms of aging and stress in retinal cells, suggesting that this approach could yield significant insights.
Where this research is happening
-
Schepens Eye Research Institute
Boston, United States Active
Researchers
- Principal investigator: Gregory-Ksander, Meredith — Schepens Eye Research Institute
- Study coordinator: Gregory-Ksander, Meredith
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.