Restoring the heart's energy in heart failure
Metabolic Resuscitation in Heart Failure.
This project looks at ways to revive the heart’s energy systems to help people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11101375 on NIH RePORTER |
What this research studies
Researchers are studying a newly identified "metabolic resuscitation system" that appears turned down in failing hearts. They will use patient-related genetic animal models and laboratory experiments, including gene-editing tools, to see how changing key factors affects heart energy and function. The team will search for measurable signals in blood or tissue that could become biomarkers and test whether manipulating these factors improves heart performance in models tied to human genetics. Findings could point to new drug targets or tests to guide future clinical trials.
Who could benefit from this research
Good fit: Adults with heart failure, especially those with reduced heart function, would be the most relevant group to follow the results or be candidates for future related clinical work.
Not a fit: People without heart failure or whose condition is caused by non-metabolic issues may not see direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could reveal new treatment targets or biomarkers that improve diagnosis, prevention, or care for people with heart failure.
How similar studies have performed: Some metabolic approaches have shown promise in animal models and early human work, but targeting this specific metabolic resuscitation system is a novel and largely untested approach in patients.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Chang, Jiang — Texas A&m University Health Science Ctr
- Study coordinator: Chang, Jiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.