Restoring muscle regeneration in older adults
Restoring the regenerative capacity of the aged muscle
This study is looking at how a special protein called NANOG can help older adults regain muscle strength and function by improving the way their muscle cells repair themselves, with the hope of creating new treatments for age-related muscle loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10862560 on NIH RePORTER |
What this research studies
This research investigates how to reverse age-related muscle loss, known as sarcopenia, which significantly impacts the elderly's health and mobility. The team has discovered that a specific protein, NANOG, can rejuvenate aging muscle stem cells, allowing them to regain their ability to regenerate muscle tissue effectively. By studying the mechanisms behind NANOG's effects, the researchers aim to develop new therapies that could enhance muscle repair and function in older individuals. This work involves both laboratory experiments and potential applications in living organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle loss or related mobility issues.
Not a fit: Patients who are younger than 21 or do not have age-related muscle degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore muscle function and improve quality of life for older adults suffering from muscle degeneration.
How similar studies have performed: Previous research has shown promising results in using similar approaches to rejuvenate aging cells, indicating potential for success in this area.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Andreadis, Stelios Theoharis — State University of New York at Buffalo
- Study coordinator: Andreadis, Stelios Theoharis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.