Restoring muscle function after nerve injury
Restoration of Muscular Function Following Direct Muscle Neurotization
This study is looking at a new way to help people recover muscle function after nerve injuries by connecting nerves directly to muscles, and it aims to make this method even better with a special support system, so patients can heal and regain strength more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Renerva, LLC NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10699345 on NIH RePORTER |
What this research studies
This research focuses on improving recovery of muscle function following peripheral nerve injuries, which affect millions of Americans. It explores a novel technique called direct muscle neurotization (DMN), where a nerve is directly connected to a muscle to promote healing without relying on existing nerve pathways. The study aims to enhance the effectiveness of this approach by developing a specialized Peripheral Nerve Matrix (PNM) that supports nerve regeneration and muscle reinnervation. Patients may benefit from improved surgical outcomes and functional recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced peripheral nerve injuries and are seeking options for restoring muscle function.
Not a fit: Patients with intact nerve function or those who do not have muscle atrophy due to nerve injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better recovery of muscle function for patients with nerve injuries.
How similar studies have performed: Previous research has shown promise in nerve regeneration techniques, but the specific approach of direct muscle neurotization is still being explored and is considered innovative.
Where this research is happening
Pittsburgh, United States
- Renerva, LLC — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Soletti, Lorenzo — Renerva, LLC
- Study coordinator: Soletti, Lorenzo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.