Restoring gut bacteria after stem cell transplants
Official title: Intestinal microbiome restoration in allogeneic stem cell transplantation
Funded at Sloan-Kettering Inst Can Research · NIH-11092862 · Data updated 2026-11-12
This study is looking at how restoring the good bacteria in your gut might help improve recovery for patients getting stem cell transplants, especially those dealing with complications from graft-versus-host disease (GVHD), by using a treatment called fecal microbiota transplantation (FMT).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $442,500 |
| NIH project number | 5R01HL164902-03 |
| Project ID | NIH-11092862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled to undergo allogeneic stem cell transplantation who are at risk for graft-versus-host disease.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those with pre-existing severe gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates how restoring the intestinal microbiome can improve outcomes for patients undergoing allogeneic stem cell transplantation. It focuses on the complications that arise from graft-versus-host disease (GVHD), which can be exacerbated by current immunosuppressive therapies. The study aims to explore fecal microbiota transplantation (FMT) as a method to enhance microbiome diversity and potentially reduce the incidence of GVHD and other transplant-related complications. By analyzing the gut microbiota before and after transplantation, the research seeks to establish a link between microbiome health and patient recovery.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing stem cell transplants.
How similar studies have gone: Previous studies have shown that fecal microbiota transplantation can safely restore microbiota diversity in similar patient populations, indicating a promising approach.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Ponce, Doris — Sloan-Kettering Inst Can Research
- Study coordinator: Ponce, Doris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.