Restoring gut bacteria after stem cell transplants
Intestinal microbiome restoration in allogeneic stem cell transplantation
This study is looking at how restoring the good bacteria in your gut might help improve recovery for patients getting stem cell transplants, especially those dealing with complications from graft-versus-host disease (GVHD), by using a treatment called fecal microbiota transplantation (FMT).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11092862 on NIH RePORTER |
What this research studies
This research investigates how restoring the intestinal microbiome can improve outcomes for patients undergoing allogeneic stem cell transplantation. It focuses on the complications that arise from graft-versus-host disease (GVHD), which can be exacerbated by current immunosuppressive therapies. The study aims to explore fecal microbiota transplantation (FMT) as a method to enhance microbiome diversity and potentially reduce the incidence of GVHD and other transplant-related complications. By analyzing the gut microbiota before and after transplantation, the research seeks to establish a link between microbiome health and patient recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled to undergo allogeneic stem cell transplantation who are at risk for graft-versus-host disease.
Not a fit: Patients who are not undergoing stem cell transplantation or those with pre-existing severe gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing stem cell transplants.
How similar studies have performed: Previous studies have shown that fecal microbiota transplantation can safely restore microbiota diversity in similar patient populations, indicating a promising approach.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Ponce, Doris — Sloan-Kettering Inst Can Research
- Study coordinator: Ponce, Doris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.