Restoring breathing in patients with spinal cord injuries using spinal stimulation.
Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI.
This study is exploring a new way to help people with spinal cord injuries breathe on their own again by using gentle electrical stimulation on their neck, which could be a safer and more natural option than relying on machines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10915382 on NIH RePORTER |
What this research studies
This research investigates a novel approach to restore natural breathing in patients with spinal cord injuries who are dependent on mechanical ventilation. By using electrical stimulation on the cervical spine, which is more accessible than deep brain structures, the study aims to activate a newly identified spinal respiratory circuit. This method seeks to provide a more responsive and integrated breathing pattern compared to traditional mechanical ventilation, which is often invasive and carries significant risks. The research involves early clinical trials to assess the effectiveness and safety of this stimulation technique.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with spinal cord injuries who experience respiratory failure and require mechanical ventilation.
Not a fit: Patients with respiratory failure due to conditions unrelated to spinal cord injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for ventilator-dependent patients by restoring their ability to breathe naturally.
How similar studies have performed: Previous research has shown promise in using spinal stimulation techniques for respiratory control, indicating potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lu, Daniel — University of California Los Angeles
- Study coordinator: Lu, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.