Restoring balance between lung cells to treat fibrosis
Targeting CEBPA To Restore Epithelial-Mesenchymal Homeostasis In Lung Fibrosis
This study is looking at how to help the lungs heal better by balancing two types of cells that are important for lung health, especially for people dealing with lung fibrosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10633272 on NIH RePORTER |
What this research studies
This research investigates how to restore the balance between epithelial and mesenchymal cells in the lungs, which is crucial for healing and maintaining lung function. It focuses on understanding the communication between these cell types during lung injury and fibrosis, aiming to identify ways to enhance the body's natural healing processes. The approach involves using advanced techniques like CRISPR to activate specific genes that can help counteract fibrosis and promote recovery. By targeting these mechanisms, the research seeks to develop new therapeutic strategies for patients suffering from lung fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary fibrosis or related lung conditions.
Not a fit: Patients with acute lung injuries not related to fibrosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and quality of life for patients with pulmonary fibrosis.
How similar studies have performed: Other research has shown promise in using gene activation techniques to address fibrosis, indicating that this approach may be viable.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Tan, Qi — University of Minnesota
- Study coordinator: Tan, Qi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.