reSET digital program to help people with HIV reduce stimulant use and stay on HIV treatment
Official title: reSET for the Treatment of Stimulant Use in HIV Clinics: Care Optimization Supporting Treatment Adherence (COSTA)
Funded at University of Miami School of Medicine · NIH-10896996 · Data updated 2026-11-12
A 12-week all-virtual reSET program offers adults living with HIV who use stimulants support to cut drug use and improve adherence to HIV medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,056,408 |
| NIH project number | 5R01DA055563-03 |
| Project ID | NIH-10896996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+) living with HIV who are on antiretroviral therapy, currently use stimulants, and receive care at participating HIV clinics in selected U.S. metropolitan areas.
✕Less likely to help
People who are not living with HIV, do not use stimulants, are under 21, or do not receive care at the participating clinics are unlikely to be eligible or to benefit from this program.
What this research studies
You would join a 12-week, all-virtual program using reSET, an FDA-approved prescription digital therapeutic that delivers behavioral treatment for stimulant use. The study will randomly assign 426 adults on antiretroviral therapy at participating HIV clinics to either the reSET program or a referral to standard outpatient substance use treatment. All activities are delivered remotely so you can participate from home while the research team tracks stimulant use and HIV outcomes like viral load. The aim is to find out whether this digital program helps people with HIV reduce stimulant use and keep their HIV medicines working well.
Why it matters
Potential benefit: If successful, this could help people with HIV who use stimulants reduce drug use and achieve better viral suppression through a convenient, remote program.
How similar studies have gone: Prior studies found reSET effective for reducing stimulant use among patients with stimulant use disorder and as a stand-alone treatment in incarcerated populations, but it has not been tested in HIV clinic settings.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Szapocznik, Jose — University of Miami School of Medicine
- Study coordinator: Szapocznik, Jose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.