Reprogramming retinal cells to restore vision
Reprogramming adult murine Müller glia via L-Myc expression
['FUNDING_FELLOWSHIP'] · VANDERBILT UNIVERSITY · NIH-10914650
This study is looking at a way to help special cells in the eye called Müller glia heal and create new nerve cells after injury or disease, using a factor called L-Myc, which could lead to new treatments for vision loss.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10914650 on ClinicalTrials.gov |
What this research studies
This research investigates how to reprogram Müller glia cells in the retina to promote regeneration after injury or disease. By using a factor called L-Myc, the study aims to stimulate these cells to re-enter the cell cycle and potentially differentiate into new retinal neurons. The approach involves using murine retinal tissue as a model to observe the effects of L-Myc on cell behavior and gene expression. If successful, this could lead to new treatments for vision loss caused by retinal damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing vision loss due to retinal injury or degenerative diseases.
Not a fit: Patients with retinal conditions that do not involve Müller glia or those who are not experiencing any vision impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel therapeutic approach to restore vision in patients with retinal damage.
How similar studies have performed: While the approach of reprogramming retinal cells is innovative, similar strategies in other contexts have shown promise, suggesting potential for success.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STONE, MEGAN — VANDERBILT UNIVERSITY
- Study coordinator: STONE, MEGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.