Reprogramming of pericytes in fibrosis
Official title: Pericyte reprogramming in fibrosis
Funded at Yale University · NIH-10896140 · Data updated 2026-11-12
This study is looking at how certain cells around blood vessels, called pericytes, change into another type of cell that helps cause scarring in tissues, which can lead to fibrosis, and the goal is to find new ways to treat this condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $483,251 |
| NIH project number | 5R01EB033917-02 |
| Project ID | NIH-10896140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from fibrotic diseases, particularly those with conditions affecting the microvasculature.
✕Less likely to help
Patients with acute injuries or conditions unrelated to fibrosis may not receive any benefit from this research.
What this research studies
This research investigates how pericytes, which are specialized cells associated with blood vessels, contribute to the development of fibrosis, a condition characterized by excessive tissue scarring. The study focuses on understanding the transition of pericytes into myofibroblasts, which are cells that play a significant role in tissue remodeling and fibrosis progression. By exploring the mechanisms behind this cellular change, the research aims to uncover new insights into the microvascular dysfunction that accelerates fibrotic diseases. Patients may benefit from findings that could lead to novel therapeutic strategies targeting these cellular processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse fibrosis, improving patient outcomes.
How similar studies have gone: Other research has shown promising results in understanding the role of pericytes in fibrosis, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Gonzalez, Anjelica — Yale University
- Study coordinator: Gonzalez, Anjelica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.