Reprogramming immune cells to stop cancer growth
Reprogramming myeloid cells to inhibit cancer development
This research explores how to change certain immune cells to prevent breast cancer from developing and growing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11141901 on NIH RePORTER |
What this research studies
Our bodies have immune cells called myeloid cells, which can sometimes help cancer grow instead of fighting it. This project aims to understand how these cells are controlled and how they support cancer development. We are focusing on a specific protein, LILRB3, found on these immune cells, which seems to play a role in helping cancer. By developing special blocking antibodies, we hope to reprogram these cells to stop supporting cancer and instead help the body fight it.
Who could benefit from this research
Good fit: This foundational research is relevant for breast cancer patients, especially those whose tumors are influenced by immune system interactions.
Not a fit: Patients with cancers not involving the specific immune cell pathways targeted by LILRB3 may not directly benefit from this particular approach.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reprogram a patient's own immune system to fight breast cancer more effectively.
How similar studies have performed: Other studies targeting immune checkpoints have shown success in cancer treatment, suggesting promise for this novel target within the same family of immune regulators.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Zhang, Chengcheng — Ut Southwestern Medical Center
- Study coordinator: Zhang, Chengcheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.