Reprogramming immune cells to improve their ability to fight chronic viral infections
Official title: CD8+ T CELL REPROGRAMMING TO BOOST ANTIVIRAL POTENTIAL AGAINST CHRONIC INFECTION
Funded at Pontificia Universidad Javeriana · NIH-10789210 · Data updated 2026-11-12
This study is looking at a new way to make your immune cells, called CD8+ T cells, even better at fighting off long-lasting viral infections like HIV and Hepatitis B, by giving them special properties that help them survive and work more effectively.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pontificia Universidad Javeriana NIH-funded |
| Lab location | 1 site (Bogota, Colombia) |
| Project start | August 12, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $54,000 |
| NIH project number | 1R03AI180633-01 |
| Project ID | NIH-10789210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic viral infections such as HIV or Hepatitis B who are seeking new treatment options.
✕Less likely to help
Patients with acute viral infections or those who do not have chronic viral infections may not benefit from this research.
What this research studies
This research focuses on enhancing the antiviral capabilities of CD8+ T cells, which are crucial for controlling chronic viral infections like HIV and Hepatitis B. The approach involves reprogramming these immune cells to develop 'stem-like' properties that improve their survival and functionality. By using specific drugs and techniques, the researchers aim to boost the effectiveness of these reprogrammed T cells in fighting off chronic infections. Patients may benefit from this innovative method that seeks to improve their immune response against persistent viral threats.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with chronic viral infections, potentially enhancing their immune response and quality of life.
How similar studies have gone: Previous studies have shown promise in reprogramming T cells to enhance their antiviral functions, suggesting that this approach may be effective.
Where this research is happening
-
Pontificia Universidad Javeriana
Bogota, Colombia Active
Researchers
- Principal investigator: Perdomo, Federico — Pontificia Universidad Javeriana
- Study coordinator: Perdomo, Federico
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.