Reprogramming immune cells to fight brain tumors
Reprograming Macrophages and Targeting Glioma Stem Cells in Glioblastoma
This study is looking at ways to help the immune system fight glioblastoma, a tough brain tumor, by changing certain immune cells called macrophages so they can better attack the tumor, and it's for anyone affected by this condition who wants to see new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10894800 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain tumor, and aims to reprogram certain immune cells called macrophages to enhance their ability to attack tumor cells. By converting tumor-promoting macrophages into tumor-suppressive ones, the study seeks to improve the immune response against glioma stem cells, which are known to contribute to tumor growth and resistance to treatment. The researchers are using innovative screening methods to identify small molecules that can facilitate this reprogramming and enhance macrophage activity against glioblastoma cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who may benefit from novel immunotherapeutic approaches.
Not a fit: Patients with other types of brain tumors or those not diagnosed with glioblastoma may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with glioblastoma by enhancing the body's immune response against the tumor.
How similar studies have performed: Other research has shown promise in reprogramming immune cells to combat various cancers, suggesting that this approach may be effective for glioblastoma as well.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Bao, Shideng — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Bao, Shideng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.