Reprogramming immune cells in lymph nodes to fight cancer spread
Official title: Reprogramming Antigen Presenting Cells in Lymph Nodes to Overcome Tumor Immune Tolerance
Funded at Stanford University · NIH-11056680 · Data updated 2026-11-12
This study is looking at how we can change certain immune cells in the body to help the immune system better fight cancer, especially when it has spread, and it aims to find new treatments that could help patients like you have a stronger response against tumors.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,520 |
| NIH project number | 5F32CA281087-02 |
| Project ID | NIH-11056680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with metastatic cancer who may benefit from enhanced immune responses.
✕Less likely to help
Patients with early-stage cancer or those not experiencing immune tolerance may not receive benefits from this research.
What this research studies
This research investigates how certain immune cells in lymph nodes can be reprogrammed to overcome the immune system's tolerance to tumors, which allows cancer to spread. The study focuses on identifying specific antigen-presenting cells (APCs) that contribute to this tolerance and exploring therapeutic strategies to modify these cells. By understanding the mechanisms behind tumor-induced immune tolerance, the research aims to develop new approaches to enhance the immune response against metastatic cancer. Patients may benefit from potential new treatments that could improve their immune system's ability to fight cancer.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the immune system's ability to combat metastatic cancer.
How similar studies have gone: Other research has shown promise in reprogramming immune cells to enhance anti-tumor responses, indicating that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Hayashi, Kazukuni — Stanford University
- Study coordinator: Hayashi, Kazukuni
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.