Reprogramming brain cells after stroke in older mice
Direct Reprogramming of the brain after ischemic stroke in the aged mouse
This study is exploring a new way to help the brain heal after a stroke by turning certain support cells into brain cells, which could lead to better recovery, especially for older people who are more likely to have strokes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10931633 on NIH RePORTER |
What this research studies
This research investigates a novel approach to repair the brain after ischemic stroke by reprogramming non-neuronal cells called astrocytes into functional neurons. Using a technique that involves delivering a specific gene, NeuroD1, to these astrocytes, the researchers aim to convert them directly into neurons without going through a stem cell stage. This method takes advantage of the body's natural response to injury, potentially leading to improved recovery and brain function. The study focuses on aged mice to understand how this process can be applied to older populations who are at higher risk for stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research would be older adults who have experienced an ischemic stroke.
Not a fit: Patients who have not suffered a stroke or those with other neurological conditions unrelated to ischemic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance brain repair and recovery in stroke patients, particularly in older adults.
How similar studies have performed: Other research has shown promising results in reprogramming cells for brain repair, indicating that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wei, Ling — Emory University
- Study coordinator: Wei, Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.