RePORT‑Brazil: a tuberculosis patient and contact network
Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network
Following people with pulmonary tuberculosis and their close contacts in Brazil to learn how to find TB earlier, treat it better, and prevent it, including when HIV is involved.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11251266 on NIH RePORTER |
What this research studies
You or a family member with TB would be enrolled and followed over time with regular clinic visits, health questions, and routine tests. The team collects samples like blood and sputum that are stored for lab and genetic analyses to learn who gets sick, who spreads TB, and who responds to treatment. They combine clinical records with genomic and transcriptomic data and link with other regional TB/HIV databases to spot patterns. This work does not give experimental treatments but aims to improve diagnosis, treatment choices, and prevention strategies in the future.
Who could benefit from this research
Good fit: Ideal candidates are people in Brazil with active pulmonary TB and their household or close contacts, including those living with HIV or diabetes.
Not a fit: People without TB, those seeking experimental therapies, or individuals who cannot attend participating Brazilian clinics are unlikely to receive direct benefits from taking part.
Why it matters
Potential benefit: If successful, the project could lead to earlier diagnosis, better treatment choices, and stronger prevention measures that reduce illness and deaths from TB, especially for people with HIV.
How similar studies have performed: An earlier phase of RePORT‑Brazil enrolled over a thousand TB patients and their contacts and produced useful findings on TB risk, diagnostics, and treatment outcomes, so this approach has yielded meaningful insights though it is not a therapeutic trial.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Sterling, Timothy R — Vanderbilt University Medical Center
- Study coordinator: Sterling, Timothy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.