Repeated DNA segments that influence health traits
Systematic characterization of tandem repeat variants contributing to complex traits
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11196735
Researchers are looking at repeated DNA sequences to learn how they change common health traits like blood measurements.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11196735 on ClinicalTrials.gov |
What this research studies
If you take part, researchers will analyze large collections of people's genetic data to find repetitive DNA sequences called short tandem repeats (STRs) and variable number tandem repeats (VNTRs). They will combine computer-based analysis of biobank-scale sequencing with functional genomics experiments and blood or serum measurements to link specific repeat changes to traits. The team aims to identify which repeat variants drive genetic signals tied to things like blood counts and biomarkers and to understand how those changes work. Much of the work uses existing genetic and health-record data, so participation could involve contributing DNA or linking your medical data through a biobank.
Who could benefit from this research
Good fit: Ideal candidates would be people who have or are willing to contribute genomic data and linked health information such as blood tests, often via a biobank or research registry.
Not a fit: People without available genetic data or whose conditions are unrelated to the traits studied (for example, conditions not reflected in blood or serum measures) are unlikely to see direct benefit.
Why it matters
Potential benefit: If successful, this work could clarify genetic causes of common traits and point to new diagnostic markers or treatment targets.
How similar studies have performed: There is growing evidence and early genome-wide work linking tandem repeats to human traits, but systematic clinical translation is still new and being established.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GYMREK, MELISSA — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: GYMREK, MELISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.