Repairing Myelin in Multiple Sclerosis
Mechanisms by which effector T cells modulate endogenous remyelination
This project explores how immune cells in the brain affect the body's natural ability to repair myelin, which is damaged in multiple sclerosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10989930 on NIH RePORTER |
What this research studies
Multiple sclerosis (MS) is a leading cause of neurological disability in young adults, and while current treatments help with inflammation, there are no therapies to repair myelin or stop the disease from getting worse. This project aims to understand why myelin repair often fails in MS, focusing on how certain immune cells, called T cells, might prevent this repair. By looking closely at the pathways involved in failed repair, researchers hope to uncover new ways to help the brain heal itself. This deeper understanding is crucial for developing new treatments that can enhance myelin repair and slow down or halt the progression of MS.
Who could benefit from this research
Good fit: This research is relevant for individuals living with multiple sclerosis, particularly those experiencing progressive forms of the disease where myelin repair is a significant challenge.
Not a fit: Patients whose conditions are unrelated to myelin damage or immune system interactions in the brain may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that help the brain repair damaged myelin, potentially slowing or stopping the progression of multiple sclerosis.
How similar studies have performed: This project addresses a gap in current knowledge, as remarkably little is known about the specific mechanisms by which immune cells affect myelin repair, making this a novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Calabresi, Peter a — Johns Hopkins University
- Study coordinator: Calabresi, Peter a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.