Repairing injuries to the pubovisceral muscle after childbirth
Pubovisceral muscle enthesis injury: A bioinspired approach to repair
This study is looking at how injuries to a specific muscle during vaginal childbirth can lead to pelvic organ prolapse later on, and it aims to create a new healing method to help women recover better than with standard surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project ID | NIH-11193226 on NIH RePORTER |
What this research studies
This research investigates injuries to the pubovisceral muscle that can occur during vaginal childbirth, which may lead to pelvic organ prolapse (POP) later in life. The study aims to understand the structure and function of the muscle and the biological processes that occur after an injury. By developing a bioinspired composite scaffold designed to promote healing, the researchers hope to improve surgical outcomes for women suffering from POP. This innovative approach seeks to provide a more effective treatment option compared to traditional suture repair methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced vaginal childbirth and are at risk of or suffering from pelvic organ prolapse.
Not a fit: Patients who have not given birth vaginally or those who do not have pelvic organ prolapse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical techniques for repairing pelvic organ prolapse, enhancing recovery and quality of life for affected women.
How similar studies have performed: While the approach of using bioinspired scaffolds is innovative, similar strategies in tissue engineering have shown promise in other areas of medicine, suggesting potential for success in this context.
Where this research is happening
Pittsburgh, UNITED STATES
- Magee-Women's Res Inst and Foundation — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Moalli, Pamela a. — Magee-Women's Res Inst and Foundation
- Study coordinator: Moalli, Pamela a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.