Repairing damage to blood vessel linings after trauma
Endothelial Glycocalyx Disintegrity: Repairing the Damage caused by Trauma-Hemorrhage
This study is looking at how injuries and bleeding can harm a protective layer on blood vessels, and it aims to find ways to prevent that damage and help the body heal, which could lead to better recovery for people who have experienced serious trauma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10863839 on NIH RePORTER |
What this research studies
This research focuses on understanding how trauma and hemorrhage damage the endothelial glycocalyx, a protective layer on blood vessels. It aims to develop strategies to prevent this damage and promote repair, which could help reduce complications like multi-organ failure. The approach involves studying the role of specific proteins and signaling pathways that affect the integrity of the glycocalyx. By identifying therapeutic targets, the research seeks to improve outcomes for patients who experience traumatic injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced trauma or severe hemorrhage.
Not a fit: Patients with chronic conditions unrelated to trauma or those who are not experiencing acute injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that minimize organ damage and improve survival rates after traumatic injuries.
How similar studies have performed: Other research has shown promise in targeting endothelial dysfunction and glycocalyx integrity, indicating that this approach could be effective.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Richter, Jillian Rouse — University of Alabama at Birmingham
- Study coordinator: Richter, Jillian Rouse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.