Renal problems in Cockayne Syndrome and NAD+ metabolism
Official title: Evaluating the renal complications in Cockayne Syndrome
Funded at Mercer University Macon · NIH-11418601 · Data updated 2026-11-12
This project looks at why people with Cockayne Syndrome develop kidney problems and whether boosting NAD+ metabolism could help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mercer University Macon NIH-funded |
| Lab location | 1 site (Macon, United States) |
| Project start | August 1, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $178,400 |
| NIH project number | 1R16DK149033-01A1 |
| Project ID | NIH-11418601 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with Cockayne Syndrome, particularly those with kidney involvement or risk of renal dysfunction.
✕Less likely to help
Patients without kidney involvement or those not eligible for any related biomarker studies may not benefit directly.
What this research studies
Cockayne Syndrome causes multi-system aging and kidney issues, and this grant seeks to understand how NAD+ depletion contributes to renal injury. The researchers will study the role of ATF3 and QPRT in the kidney’s NAD+ pathway and how this leads to cell damage. They plan experiments to define the molecular steps and test potential strategies to restore NAD+ levels and protect kidney cells. The work could point to new therapies that target NAD+ metabolism for patients with CS who struggle with kidney function.
Why it matters
Potential benefit: If successful, the work could lead to therapies that protect kidney function in Cockayne Syndrome by restoring NAD+ metabolism.
How similar studies have gone: Previous studies have linked NAD+ depletion to cellular stress and organ dysfunction; this proposal builds on those insights in CS and kidney cells.
Where this research is happening
-
Mercer University Macon
Macon, United States Active
Researchers
- Principal investigator: Lee, Jong-Hyuk — Mercer University Macon
- Study coordinator: Lee, Jong-Hyuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.