NIH-funded research R01 grant

Removing fallopian tubes to lower ovarian cancer risk

Official title: Salpingectomy for Ovarian Cancer Risk Reduction: Improving Utilization and Informed Decision-Making

Funded at Columbia University Health Sciences · NIH-10932137 · Data updated 2026-11-12

This study is looking at how removing fallopian tubes can help lower the risk of ovarian cancer and aims to find out why doctors might not suggest this option to patients, while also helping women understand its benefits better.

More Ovarian Cancer research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences
NIH-funded
Lab location1 site (New York, United States)
Project startSeptember 30, 2022
Project endSeptember 29, 2027
Funding year2024
Award (this year)$327,979
NIH project number5R01HS028612-03
Project IDNIH-10932137 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are women who are considering sterilization or those at increased risk for ovarian cancer.

Less likely to help

Patients who have already undergone hysterectomy with ovary removal or those without risk factors for ovarian cancer may not benefit from this research.

What this research studies

This research investigates the benefits of prophylactic salpingectomy, which involves the removal of fallopian tubes while preserving the ovaries, as a method to reduce the risk of ovarian cancer. The study aims to identify barriers that prevent healthcare providers from recommending this procedure and to enhance patient awareness regarding its potential benefits. By focusing on improving decision-making and utilization of salpingectomy, the research seeks to promote better preventive care for women at risk of ovarian cancer. The findings could lead to increased adoption of this safer alternative to traditional prophylactic ovary removal.

Why it matters

Potential benefit: If successful, this research could significantly reduce the incidence of ovarian cancer in women while minimizing the negative health impacts associated with surgical menopause.

How similar studies have gone: Previous research has indicated that salpingectomy can effectively reduce ovarian cancer risk, suggesting that this approach has potential for success.

Where this research is happening

  • Columbia University Health Sciences
    New York, United States
    Active

Researchers

  • Principal investigator: Xu, Xiao — Columbia University Health Sciences
  • Study coordinator: Xu, Xiao

Related research

Other NIH-funded projects on the same topics.

  • Salpingectomy to Cut Ovarian Cancer Risk: Improving Use and Informed Choices

    A project at Columbia University aims to help women reduce ovarian cancer risk by removing the fallopian tubes during other surgeries, while keeping the ovaries intact, and to make sure patients and providers understand the benefits and options.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11421121

  • Fallopian tube removal to prevent ovarian cancer

    This project uses removal of the fallopian tubes while keeping the ovaries to lower ovarian cancer risk for people having hysterectomy or choosing permanent sterilization.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11191424

  • Understanding how octopuses integrate sensory information and make decisions

    This study is exploring how octopuses use their arms to grip things by looking closely at their nervous system and movements, which could help us understand their amazing abilities better.

    NIH research Michigan State University · East Lansing, United States · NIH-9949982

  • NoviGuide for Newborn Care in Pakistan

    A small NIH grant to test a pocket-sized decision support tool for nurses and doctors to improve newborn care in Pakistan.

    NIH research Aga Khan University (Pakistan) · Karachi, Pakistan · NIH-11624823

  • Understanding the experience of ovarian cancer after diagnosis to improve survivorship

    This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.

    NIH research University of Minnesota · Minneapolis, United States · NIH-11624191

  • Understanding how aging and Alzheimer’s affect how people make tough choices

    This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.

    NIH research University of Florida · Gainesville, United States · NIH-11620311

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.