Remote, self‑administered memory and thinking tests to detect early Alzheimer’s changes
Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease
Short, self‑administered digital memory and thinking tests are being used with people who have early or at‑risk Alzheimer’s disease to find and track subtle cognitive changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11233271 on NIH RePORTER |
What this research studies
You would use brief digital cognitive tasks on your smartphone, tablet, or computer that measure memory, learning, and related thinking skills. The project uses the Mayo Test Drive platform and the Stricker Learning Span task to collect results remotely or during clinic visits. Results will be compared with other clinical measures and biological markers to see how well the tests pick up early Alzheimer’s‑related change. The goal is to make a convenient test people can do at home that helps clinicians find problems sooner and monitor changes over time.
Who could benefit from this research
Good fit: Ideal candidates are older adults who are cognitively normal but at higher risk, people with subjective cognitive concerns, or those with mild cognitive impairment or biomarker evidence suggesting early Alzheimer’s disease.
Not a fit: People with advanced dementia, severe sensory or motor impairments that prevent using digital devices, or cognitive problems clearly due to non‑Alzheimer’s causes may not benefit from these specific tests.
Why it matters
Potential benefit: If successful, these brief remote tests could help catch Alzheimer’s‑related cognitive change earlier so people can get into treatment or clinical trials sooner.
How similar studies have performed: Other brief digital cognitive tools and learning‑span tasks have shown promise in research settings, but this combination and remote validation need further confirmation.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Stricker, Nikki H — Mayo Clinic Rochester
- Study coordinator: Stricker, Nikki H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.