Rejuvenating neural stem cells to improve memory and cognition in aging
Neural stem cell rejuvenation through single cell pharmacogenomics
This study is looking for ways to help brain cells that lose their ability to grow and function as we get older, especially in people with Alzheimer's, by finding new compounds that could boost their performance and improve thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11052596 on NIH RePORTER |
What this research studies
This research investigates how to rejuvenate neural stem cells (NSCs) that decline in function as we age, particularly in relation to Alzheimer's disease. By using advanced computational and pharmacogenomic techniques, the study aims to identify compounds that can enhance the proliferation and functionality of NSCs, thereby potentially improving neurogenesis and cognitive abilities. The approach includes analyzing single-cell data to understand the molecular changes that occur in NSCs with age and testing compounds that may reverse these changes. Patients may benefit from insights that could lead to new treatments for age-related cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for Alzheimer's disease.
Not a fit: Patients with early-stage Alzheimer's disease or those with advanced neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance memory and cognitive function in older adults, particularly those at risk for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in rejuvenating neural stem cells through pharmacogenomic approaches, indicating potential for success in this novel application.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bonaguidi, Michael — University of Southern California
- Study coordinator: Bonaguidi, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.