Rejuvenating aged stem cells to improve tissue repair and health.
Targeting H4K20 methylation to rejuvenate aged stem cell epigenome and regenerative function.
This study is looking at how getting older affects stem cells, which help keep our tissues healthy, and it aims to find ways to boost their function again, using mice and some cool science techniques, so we can improve recovery from age-related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11088443 on NIH RePORTER |
What this research studies
This research investigates how aging affects the ability of stem cells to regenerate and maintain healthy tissues. By exploring the epigenetic changes that occur in aged stem cells, the study aims to develop methods to restore their function. The approach includes using mouse models, exercise, and advanced genomic techniques to understand and potentially reverse the decline in stem cell activity. This could lead to new therapies that enhance recovery from age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related decline in tissue repair and regeneration.
Not a fit: Patients with acute conditions unrelated to aging or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve tissue regeneration and overall health in older adults.
How similar studies have performed: Previous research has shown promising results in rejuvenating stem cell function through similar epigenetic approaches, indicating potential for success in this area.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Blanc, Romeo Sebastien — University of Wisconsin-Madison
- Study coordinator: Blanc, Romeo Sebastien
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.