Regulatory T Cell Clues to Personalize SLE Therapy
Official title: Regulatory T Cell Dysfunction as a Biomarker for Personalized Therapeutic Target Identification in SLE
Funded at Weill Medical Coll of Cornell Univ · NIH-11552864 · Data updated 2026-11-12
A study to find T cell signals in lupus patients that could guide personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $647,571 |
| NIH project number | 1R56AI195877-01A1 |
| Project ID | NIH-11552864 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with SLE who have varying disease activity, including those with lupus nephritis or active organ involvement.
✕Less likely to help
People without SLE or with stable disease for whom Treg-based targeting is not relevant.
What this research studies
Researchers will look at regulatory T cells in people with systemic lupus erythematosus (SLE) using single-cell RNA profiling to find distinct patient groups. They have already found two Treg patterns, with one group showing more active disease and kidney involvement. The project aims to map these patterns to disease activity and organ damage over time and identify markers that can be measured in blood or tissues. This could pave the way for targeted therapies tailored to a patient’s Treg profile.
Why it matters
Potential benefit: If successful, this work could lead to personalized therapies based on a patient’s Treg profile and improve disease tracking.
How similar studies have gone: Previous studies have linked Treg alterations to SLE activity; this project extends those findings with single-cell analysis to guide therapy.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Caielli, Simone — Weill Medical Coll of Cornell Univ
- Study coordinator: Caielli, Simone
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.