Regulation of kidney potassium handling by Kir4.1 and Kir5.1
Official title: Regulation of Kir4.1/Kir5.1 and renal potassium excretion
Funded at New York Medical College · NIH-11372982 · Data updated 2026-11-12
This grant studies how kidney channels Kir4.1 and Kir5.1 influence potassium balance and how this affects heart and muscle health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | July 26, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $360,800 |
| NIH project number | 5R01DK136491-04 |
| Project ID | NIH-11372982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with kidney or electrolyte disorders or those at risk for potassium-related heart or muscle problems.
✕Less likely to help
Patients without electrolyte disturbances or kidney-related conditions may not directly benefit from this basic mechanistic study.
What this research studies
If successful, the project will map how Kir4.1/Kir5.1 in the kidney’s distal tubule control another key transporter (NCC) to maintain safe potassium levels during different diets. The work combines animal models to understand the cellular signaling that ties Kir channels to potassium excretion and NCC activity. Results could guide better treatments for people at risk of dangerous potassium imbalances that affect heart rhythm and muscle function.
Why it matters
Potential benefit: A better understanding of kidney potassium regulation could lead to therapies that prevent dangerous heart and muscle problems related to potassium imbalances.
How similar studies have gone: Previous studies in mice show Kir4.1/Kir5.1 modulate NCC and potassium excretion, supporting potential translational relevance.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Lin, Dao-Hong — New York Medical College
- Study coordinator: Lin, Dao-Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.