Regulation and Role of PAP in Lipid Metabolism and Diabetes
Official title: Regulation and Role of Phosphatidate Phosphatase in Lipid Metabolism
Funded at Rutgers, the State Univ of N.j. · NIH-11394388 · Data updated 2026-11-12
A study exploring how a key lipid enzyme (PAP) affects fat metabolism and its links to adult-onset diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | June 1, 2020 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $431,750 |
| NIH project number | 5R35GM136128-07 |
| Project ID | NIH-11394388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for adult-onset diabetes mellitus who are interested in contributing to biomolecular research related to lipid metabolism.
✕Less likely to help
Individuals without metabolic or lipid abnormalities may see limited direct benefit from this basic science study.
What this research studies
This research investigates how phosphatidate phosphatase (PAP) controls lipid balance in cells and how changes in PAP activity can influence diabetes-related processes. It uses insights from yeast, mouse, and human data to understand how PAP affects lipid synthesis, lipid droplets, and membrane formation. The goal is to connect PAP-related lipid changes to cellular dysfunctions seen in adult-onset diabetes and related metabolic issues.
Why it matters
Potential benefit: If successful, the project could reveal new ways to prevent or treat metabolic problems linked to diabetes by targeting PAP pathways.
How similar studies have gone: Previous work shows PAP activity profoundly influences lipid metabolism and disease features in animals and humans, supporting potential translational relevance.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Carman, George M. — Rutgers, the State Univ of N.j.
- Study coordinator: Carman, George M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.