Regeneration of the Immune System After Radiation Exposure
Funded at Albert Einstein College of Medicine · NIH-11367420 · Data updated 2026-11-12
This grant aims to understand how radiation exposure damages the immune system and how it can recover, with the goal of helping people who have been exposed to radiation.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 18, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $582,293 |
| NIH project number | 5U01AI170032-05 |
| Project ID | NIH-11367420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with or at risk for radiation-induced immune dysfunction or Acute Radiation Syndrome, and scenarios where immune recovery could be enhanced.
✕Less likely to help
Patients without radiation exposure or immune complications related to radiation are unlikely to benefit directly.
What this research studies
Researchers at Albert Einstein College of Medicine will study how radiation changes immune cells and tissues, from bone marrow to the gut and lungs, to map the recovery process. They will examine immune cell function, antigen presentation, and inflammatory signals to identify factors that promote or hinder healing after radiation. The work will involve animal and human-relevant models to explore regenerative pathways and potential countermeasures that support immune repair. Results could inform safer treatments and better care for people who suffer from Acute Radiation Syndrome and related delayed effects.
Why it matters
Potential benefit: If successful, findings could lead to improved therapies that restore immune function after radiation exposure and reduce infection risk and organ damage.
How similar studies have gone: Previous work has shown that immune regeneration after radiation is complex but potentially improves with targeted support; this project builds on those insights with a broader immune landscape analysis.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Guha, Chandan — Albert Einstein College of Medicine
- Study coordinator: Guha, Chandan
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.