Regeneration of jaw joint cartilage using tissue engineering
Tissue-engineered regeneration of the minipig TMJ condyle
This study is exploring new ways to help people with jaw joint problems by creating special implants that can repair damaged cartilage in the jaw, using techniques tested on Yucatan minipigs to find the best solutions for future treatments in humans.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11061065 on NIH RePORTER |
What this research studies
This research focuses on developing new methods to regenerate cartilage in the temporomandibular joint (TMJ) using tissue engineering techniques. It involves studying the mandibular condyle of the Yucatan minipig to create bioengineered implants that can restore damaged cartilage and bone. The project utilizes advanced imaging techniques to analyze collagen types in the joint, which is crucial for understanding how to effectively regenerate the tissue. By conducting in vivo studies, the research aims to translate these findings into potential clinical applications for humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing degeneration of the temporomandibular joint, particularly those who are 21 years or older.
Not a fit: Patients with acute TMJ injuries or those who do not have degeneration of the joint may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients suffering from TMJ degeneration, potentially improving their quality of life.
How similar studies have performed: Previous research has shown promise in using tissue engineering for cartilage regeneration, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Bielajew, Benjamin — University of California-Irvine
- Study coordinator: Bielajew, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.