Regeneration of jaw joint cartilage using tissue engineering
Official title: Tissue-engineered regeneration of the minipig TMJ condyle
Funded at University of California-Irvine · NIH-11061065 · Data updated 2026-11-12
This study is exploring new ways to help people with jaw joint problems by creating special implants that can repair damaged cartilage in the jaw, using techniques tested on Yucatan minipigs to find the best solutions for future treatments in humans.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | April 11, 2023 |
| Project end | April 10, 2026 |
| Funding year | 2025 |
| Award (this year) | $77,556 |
| NIH project number | 5F32DE032896-03 |
| Project ID | NIH-11061065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing degeneration of the temporomandibular joint, particularly those who are 21 years or older.
✕Less likely to help
Patients with acute TMJ injuries or those who do not have degeneration of the joint may not benefit from this research.
What this research studies
This research focuses on developing new methods to regenerate cartilage in the temporomandibular joint (TMJ) using tissue engineering techniques. It involves studying the mandibular condyle of the Yucatan minipig to create bioengineered implants that can restore damaged cartilage and bone. The project utilizes advanced imaging techniques to analyze collagen types in the joint, which is crucial for understanding how to effectively regenerate the tissue. By conducting in vivo studies, the research aims to translate these findings into potential clinical applications for humans.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients suffering from TMJ degeneration, potentially improving their quality of life.
How similar studies have gone: Previous research has shown promise in using tissue engineering for cartilage regeneration, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Bielajew, Benjamin — University of California-Irvine
- Study coordinator: Bielajew, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.