Regenerating skin for treating severe burn wounds in children
In Situ Skin Regeneration through Induction of Skin Allograft Chimerism for Treatment of Severe Burn Wounds
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11052645
This study is exploring a new way to help kids with severe burn wounds heal faster and better by using special skin grafts and a combination of two medicines that encourage skin to grow back naturally.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11052645 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to heal severe burn wounds by using skin allografts that can regenerate skin tissue. The study aims to overcome the challenges of skin graft rejection and long healing times by employing a two-drug combination therapy that promotes skin regeneration. By utilizing stem cell mobilization, the researchers hope to achieve better healing outcomes, particularly for children who suffer from severe burns. The goal is to create a method that not only covers the wounds but also restores the skin's natural functions and appearance.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 16 who have sustained severe burn injuries requiring skin grafts.
Not a fit: Patients with minor burns or those who do not require skin grafts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve healing outcomes for children with severe burn injuries, reducing scarring and enhancing skin function.
How similar studies have performed: While the approach of using stem cell mobilization for skin regeneration is innovative, similar strategies in organ transplantation have shown promise, suggesting potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, ZHAOLI — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SUN, ZHAOLI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus