Regenerating skeletal muscle to treat severe muscle loss
Regenerating Vascularized and Innervated Skeletal Muscle to Treat VML Defects
This study is looking at new ways to help people with serious muscle damage by using special cells and materials to grow new muscle tissue, with the goal of helping them regain normal muscle function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11124553 on NIH RePORTER |
What this research studies
This research focuses on developing new therapies to regenerate skeletal muscle tissue that has been severely damaged due to volumetric muscle loss (VML). It utilizes human skeletal muscle stem cells combined with innovative biomaterials to create 3D muscle grafts. The approach involves growing these cells on specialized microfibers to encourage their growth and alignment, ultimately aiming to restore normal muscle function. The study also explores the use of specific growth factors to enhance muscle regeneration and the formation of neuromuscular junctions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant muscle loss due to trauma or surgical removal.
Not a fit: Patients with intact muscle tissue or those with conditions unrelated to muscle regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for patients suffering from severe muscle injuries, improving their recovery and quality of life.
How similar studies have performed: Previous research has shown promise in using tissue engineering and stem cell approaches for muscle regeneration, indicating a potential for success in this novel application.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Grayson, Warren L — Johns Hopkins University
- Study coordinator: Grayson, Warren L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.