Regenerating muscle tissue to treat severe muscle injuries
Regenerating Vascularized and Innervated Skeletal Muscle to Treat VML Defects
This study is exploring new ways to help people with serious muscle injuries by using special cells and materials to grow new muscle tissue that can help them regain normal movement and strength.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10868617 on NIH RePORTER |
What this research studies
This research focuses on developing new methods to regenerate skeletal muscle tissue that has been severely damaged due to traumatic injuries. By utilizing human skeletal muscle stem cells and innovative biomaterials, the project aims to create three-dimensional muscle grafts that can restore normal muscle function. The approach involves growing specific muscle progenitor cells on specially designed microfibers and enhancing their growth with certain growth factors. This could lead to effective treatments for patients suffering from volumetric muscle loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced significant muscle loss due to trauma or injury.
Not a fit: Patients with muscle loss due to non-traumatic causes or those with chronic muscle diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapies for patients with severe muscle injuries, improving their recovery and quality of life.
How similar studies have performed: Previous research in tissue engineering and muscle regeneration has shown promising results, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Grayson, Warren L — Johns Hopkins University
- Study coordinator: Grayson, Warren L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.