Regenerating jaw joint discs using 3D-printed scaffolds and stem cells
Bioactive Scaffold for TMJ Disc Regeneration by Endogenous Stem/Progenitor Cells
This study is exploring a new way to help heal the discs in the jaw joint for people with TMJ disorders by using special 3D-printed structures that encourage the body to repair itself.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10894138 on NIH RePORTER |
What this research studies
This research focuses on developing a method to regenerate the discs in the jaw joint (TMJ) using 3D-printed scaffolds that mimic natural tissue. The approach involves embedding growth factors within these scaffolds to attract and guide the body's own stem cells to repair the damaged discs. By using animal models, the researchers aim to demonstrate how these engineered scaffolds can lead to effective regeneration of the TMJ discs, potentially improving outcomes for patients with TMJ disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with temporomandibular joint disorders, particularly those experiencing internal derangement or disc displacement.
Not a fit: Patients with TMJ disorders that do not involve disc displacement or those who have already undergone extensive surgical treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option for patients suffering from TMJ disorders, reducing the need for surgical interventions.
How similar studies have performed: Previous studies have shown promising results in using 3D-printed scaffolds for tissue regeneration, indicating potential success for this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Lee, Chang Hun — Columbia University Health Sciences
- Study coordinator: Lee, Chang Hun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.