Reducing the use of vancomycin in preterm infants
Official title: Implementing vancomycin-sparing regimens in preterm infants
Funded at Children's Hosp of Philadelphia · NIH-11052526 · Data updated 2026-11-12
This study is looking at how to use antibiotics better for preterm babies in the NICU by finding ways to use gentler options instead of the stronger antibiotic vancomycin, helping to keep these little ones safer and healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $244,080 |
| NIH project number | 5R01HS029500-02 |
| Project ID | NIH-11052526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants born at or before 35 weeks of gestation who are admitted to the NICU.
✕Less likely to help
Patients who are not preterm or those who do not require antibiotic treatment in the NICU may not benefit from this research.
What this research studies
This research focuses on improving antibiotic use in neonatal intensive care units (NICUs) for preterm infants, who are often exposed to antibiotics and at risk for side effects. The study aims to implement vancomycin-sparing regimens that encourage the use of narrower spectrum antibiotics as first-line treatments. By developing protocols that guide when vancomycin is necessary, the research seeks to optimize antibiotic stewardship and enhance patient safety. The goal is to reduce the reliance on vancomycin, which is commonly used empirically for suspected infections in these vulnerable infants.
Why it matters
Potential benefit: If successful, this research could lead to safer antibiotic practices in NICUs, reducing the risk of side effects and antibiotic resistance in preterm infants.
How similar studies have gone: Previous studies have shown that vancomycin-reducing protocols can safely decrease vancomycin use in NICUs, indicating a promising approach.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Mukhopadhyay, Sagori — Children's Hosp of Philadelphia
- Study coordinator: Mukhopadhyay, Sagori
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.