Reducing the need for reintubation in high-risk cardiac surgery patients using high-flow nasal cannula.
Official title: Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula -the "I-CAN" study
Funded at Vanderbilt University Medical Center · NIH-10819218 · Data updated 2026-11-12
This study is looking at how well high-flow nasal cannula therapy can help prevent the need for reintubation in patients who have just had heart surgery, especially those with other health problems, to improve their recovery and care after the operation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | May 15, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $174,543 |
| NIH project number | 5K23HL148640-05 |
| Project ID | NIH-10819218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are undergoing high-risk cardiac surgery and may have multiple comorbidities.
✕Less likely to help
Patients who are not undergoing cardiac surgery or those with minimal health risks may not benefit from this research.
What this research studies
This research investigates the effectiveness of high-flow nasal cannula therapy in preventing reintubation among patients who have undergone cardiac surgery. The study focuses on high-risk individuals, particularly those with multiple health issues, and aims to identify strategies that can reduce the likelihood of needing to reinsert a breathing tube after surgery. By utilizing advanced clinical informatics and pragmatic trial design, the research seeks to gather data that can inform better postoperative care practices. Patients will be monitored closely to assess outcomes related to reintubation rates and overall recovery.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of reintubation, leading to improved recovery outcomes and lower healthcare costs for patients undergoing cardiac surgery.
How similar studies have gone: Previous research has shown promising results in using high-flow nasal cannula therapy in various settings, suggesting potential for success in this novel application for cardiac surgery patients.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Freundlich, Robert Edward — Vanderbilt University Medical Center
- Study coordinator: Freundlich, Robert Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.