Reducing the effects of chemotherapy on aging breast cancer survivors
Official title: Targeting Senescence to Mitigate Chemotherapy-induced Functional Decline
Funded at University of California Los Angeles · NIH-10913312 · Data updated 2026-11-12
This study is looking at how chemotherapy might speed up aging in breast cancer survivors and how it affects their physical abilities and overall quality of life, while also exploring ways, like exercise or certain medications, to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $649,152 |
| NIH project number | 5R01CA280088-02 |
| Project ID | NIH-10913312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer survivors who have experienced chemotherapy and are facing functional decline as they age.
✕Less likely to help
Patients who have not undergone chemotherapy or those without a history of breast cancer may not benefit from this research.
What this research studies
This research investigates how chemotherapy affects the aging process in breast cancer survivors, particularly focusing on the decline in physical function and quality of life. It aims to understand the role of cellular senescence, a process where cells stop dividing and contribute to aging, in exacerbating these issues. By targeting and reducing senescent cells, the study explores potential interventions, such as exercise or specific drugs, to improve health outcomes for survivors. The research will involve clinical assessments and interventions to evaluate the effectiveness of these approaches.
Why it matters
Potential benefit: If successful, this research could help improve the quality of life and functional abilities of breast cancer survivors who have undergone chemotherapy.
How similar studies have gone: Previous research has shown promise in targeting cellular senescence to improve health outcomes in aging populations, suggesting potential success for this approach in breast cancer survivors.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Sedrak, Mina S — University of California Los Angeles
- Study coordinator: Sedrak, Mina S
Related research
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This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.
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Genetic clues for doxorubicin heart risk using patient-derived heart cells
A research project tests how human heart cells grown from stem cells react to a common chemotherapy to see which genetic differences may raise the risk of heart damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.