Reducing overdose and suicide risk for adults with opioid use disorder and mental health conditions

Reducing Overdose and Suicide Risk in Individuals with OUD and Co-occurring Disorders

NIH-funded research Rand Corporation · NIH-11307133

Trying new ways to help adults with opioid use disorder and co-occurring mental health problems start and stay on lifesaving medications and reduce overdose and suicide risk after emergency department visits.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionRand Corporation NIH-funded
Lab location1 site (Santa Monica, United States)
Project IDNIH-11307133 on NIH RePORTER

What this research studies

This project partners with emergency departments, primarily within the California Bridge Program, to improve access to medications for opioid use disorder (MOUD) and strengthen follow-up care after ED visits. Researchers will use hospital and prescription-fill data and follow patients after discharge to see who fills MOUD prescriptions and who remains in treatment. The team will compare approaches to linkage and retention and pay special attention to people who have both OUD and mental health conditions. Outcomes tracked include treatment retention, overdose, and self-harm so the study can identify strategies EDs can use to better prevent deaths.

Who could benefit from this research

Good fit: Adults (21+) with opioid use disorder and co-occurring mental health conditions who visit participating emergency departments—especially hospitals in the California Bridge Program—are the ideal candidates.

Not a fit: People under 21, those without opioid use disorder, or patients who do not visit participating EDs or cannot access outpatient MOUD services may not directly benefit from this project.

Why it matters

Potential benefit: If successful, the work could help more people start and remain on life-saving OUD medications and reduce overdoses and suicide.

How similar studies have performed: Previous research shows that starting and staying on MOUD reduces deaths and programs like the California Bridge have improved ED access, but long-term retention and suicide prevention remain challenging, so this project builds on proven approaches while addressing gaps.

Where this research is happening

Santa Monica, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.