Reducing organ dysfunction in older patients after trauma.
Official title: Attenuation of Multiorgan Dysfunction after Shock in the Aged
Funded at University of California, San Diego · NIH-11083118 · Data updated 2026-11-12
This study is looking at how to help older patients recover better after experiencing trauma or shock by blocking harmful digestive enzymes that can leak into their blood and affect their organs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $325,164 |
| NIH project number | 5R01AG083015-03 |
| Project ID | NIH-11083118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have experienced trauma or shock.
✕Less likely to help
Patients who are younger or do not have a history of trauma or shock may not benefit from this research.
What this research studies
This research investigates how to prevent multiple organ dysfunction in older patients who experience trauma or shock. It focuses on the role of digestive enzymes that leak into the bloodstream and cause harm to various organs. By blocking these enzymes, the study aims to improve recovery outcomes for aged individuals. The approach is based on previous successful trials in younger patients and seeks to address the unique challenges faced by older adults.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and quality of life for older patients after traumatic events.
How similar studies have gone: Previous studies have shown success in younger populations using similar approaches, indicating potential for effectiveness in older patients.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Schmid-Schoenbein, Geert W. — University of California, San Diego
- Study coordinator: Schmid-Schoenbein, Geert W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.