Reducing obesity-related cancer risk
Early Phase Clinical Cancer Prevention Consortium
This consortium tests new prevention approaches to lower cancer risk linked to obesity for people at higher risk of breast and other cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11221944 on NIH RePORTER |
What this research studies
As someone worried about cancer, you should know this program brings together lab and clinical teams to design early-phase prevention trials that aim to reverse obesity-driven changes that raise cancer risk. The group creates and reviews candidate treatments, picks trial designs, and uses lab biomarkers to track how the treatments affect cancer-related biology. The consortium currently runs multiple early-phase prevention trials across breast, colorectal, esophageal, endometrial and genitourinary cancers and coordinates work among affiliated cancer centers. Trials are built to combine laboratory findings with real patient testing to identify approaches that could reduce future cancer risk.
Who could benefit from this research
Good fit: Ideal candidates are adults with obesity or related metabolic or genomic risk factors who are eligible for early-phase cancer prevention trials at affiliated centers.
Not a fit: People with active, untreated cancer or those who do not meet specific trial eligibility criteria or have medical contraindications may not receive benefit from these prevention trials.
Why it matters
Potential benefit: If successful, these trials could lower future cancer risk for people with obesity by reversing biological pathways that expand cancer stem cell pools.
How similar studies have performed: Previous early-phase prevention and biomarker-guided trials have shown promising changes in risk markers, but clear long-term cancer-prevention success is still being established.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Schuetze, Scott Michael — University of Michigan at Ann Arbor
- Study coordinator: Schuetze, Scott Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.