Reducing new HIV infections in rural South Africa after COVID-19

The changing face of HIV in the era of COVID-19: Maximising HIV incidence reduction through dynamic targeting of current and future distributions of acquisition risk.

NIH-funded research Stellenbosch University · NIH-11489927

This project finds who in rural KwaZulu-Natal is now most at risk for HIV so prevention efforts can be focused to stop new infections.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionStellenbosch University NIH-funded
Lab location1 site (Stellenbosch, SOUTH AFRICA)
Project IDNIH-11489927 on NIH RePORTER

What this research studies

You would hear about work that maps who is getting safer or more at risk for HIV over time and across neighborhoods, age groups, and sexes in a large community cohort. The team uses long-running data from the Africa Health Research Institute in rural KwaZulu-Natal and looks at how changes like new HIV drugs and COVID-19 disruptions shift risk. They plan to predict emerging vulnerable groups and design combined prevention approaches aimed at those people and places. The goal is to make prevention resources reach the exact groups most likely to benefit.

Who could benefit from this research

Good fit: People living in or at risk of HIV in rural KwaZulu-Natal, South Africa—particularly specific age, sex, or neighborhood groups identified as vulnerable—would be the focus.

Not a fit: People who live outside the study area or whose HIV risk is already well-controlled or unrelated to the targeted factors are unlikely to directly benefit from this project.

Why it matters

Potential benefit: If successful, this could lower new HIV infections by concentrating prevention and care where they will have the biggest effect in poor rural communities.

How similar studies have performed: Large scale HIV treatment and prevention efforts have previously cut new infections substantially in South Africa, but using dynamic, targeted approaches to catch emerging vulnerable groups is a newer strategy.

Where this research is happening

Stellenbosch, SOUTH AFRICA

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.