Reducing lung damage from chlorine gas exposure
Official title: Electrophilic Fatty Acids Reduce Chlorine-Lung Toxicity via Inhibition of Macrophage Activation
Funded at Rutgers Biomedical and Health Sciences · NIH-11098884 · Data updated 2026-11-12
This study is looking at how some fatty acids might help protect the lungs from damage caused by chlorine gas, which can happen in accidents or during chemical attacks, and it's being tested in mice to find ways to keep our lungs healthier after such exposure.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 6, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $235,500 |
| NIH project number | 1R21ES036419-01A1 |
| Project ID | NIH-11098884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been exposed to chlorine gas, either through accidents or in military contexts.
✕Less likely to help
Patients who have not been exposed to chlorine gas or who have pre-existing severe lung conditions may not benefit from this research.
What this research studies
This research investigates how certain fatty acids can help protect the lungs from damage caused by chlorine gas, which can occur during chemical warfare or accidental exposure. The study uses a mouse model to simulate inhalation of chlorine and examines the effects of these fatty acids on lung inflammation and injury within the first 24 hours after exposure. By understanding the mechanisms involved, the research aims to identify potential treatments that could mitigate the harmful effects of chlorine on lung health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect patients from severe lung damage caused by chlorine gas exposure.
How similar studies have gone: Other research has shown promise in using fatty acids to reduce inflammation and lung injury, suggesting that this approach may be effective.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Gow, Andrew J — Rutgers Biomedical and Health Sciences
- Study coordinator: Gow, Andrew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.