Reducing insulin levels to improve heart health in type 1 diabetes
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
This study is looking at whether lowering high insulin levels in people with type 1 diabetes can help their heart health and overall well-being, and if you join, you might get access to new treatments that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10980044 on NIH RePORTER |
What this research studies
This research investigates how lowering excessive insulin levels in patients with type 1 diabetes can enhance their heart health and overall metabolic function. It focuses on the concept of iatrogenic hyperinsulinemia, where patients receive insulin in a way that may lead to higher than necessary insulin levels in the bloodstream. By exploring insulin adjunctive therapies, the study aims to determine if these approaches can improve insulin sensitivity and reduce cardiovascular disease risk. Patients participating in this research may receive new treatment options that could lead to better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with type 1 diabetes who are managing their blood glucose levels.
Not a fit: Patients with type 2 diabetes or those who do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly lower the risk of cardiovascular disease in individuals with type 1 diabetes.
How similar studies have performed: Previous studies have indicated that addressing insulin delivery methods can lead to improved metabolic outcomes, suggesting a promising avenue for this research.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Gregory, Justin — Vanderbilt University Medical Center
- Study coordinator: Gregory, Justin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.