Reducing insulin levels to improve heart health in type 1 diabetes
Official title: Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
Funded at Vanderbilt University Medical Center · NIH-10980044 · Data updated 2026-11-12
This study is looking at whether lowering high insulin levels in people with type 1 diabetes can help their heart health and overall well-being, and if you join, you might get access to new treatments that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $340,747 |
| NIH project number | 1R01DK137997-01A1 |
| Project ID | NIH-10980044 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 1 diabetes who are managing their blood glucose levels.
✕Less likely to help
Patients with type 2 diabetes or those who do not have diabetes may not benefit from this research.
What this research studies
This research investigates how lowering excessive insulin levels in patients with type 1 diabetes can enhance their heart health and overall metabolic function. It focuses on the concept of iatrogenic hyperinsulinemia, where patients receive insulin in a way that may lead to higher than necessary insulin levels in the bloodstream. By exploring insulin adjunctive therapies, the study aims to determine if these approaches can improve insulin sensitivity and reduce cardiovascular disease risk. Patients participating in this research may receive new treatment options that could lead to better health outcomes.
Why it matters
Potential benefit: If successful, this research could significantly lower the risk of cardiovascular disease in individuals with type 1 diabetes.
How similar studies have gone: Previous studies have indicated that addressing insulin delivery methods can lead to improved metabolic outcomes, suggesting a promising avenue for this research.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Gregory, Justin — Vanderbilt University Medical Center
- Study coordinator: Gregory, Justin
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
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-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.