Reducing inflammation in older adults to protect organs during sepsis
Downregulation of Inflamm-aging for Protection Against Organ Damage in Sepsis
This study looks at how getting older can make inflammation and organ problems worse in older adults with sepsis, and it explores how a special protein called Klotho might help improve recovery, aiming to find better treatments for these patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10881666 on NIH RePORTER |
What this research studies
This research investigates how aging affects inflammation and organ damage in older adults suffering from sepsis. It focuses on understanding the mechanisms that lead to increased inflammation and prolonged organ dysfunction in elderly patients. By using an animal model, the study examines the role of a specific protein, Klotho, in regulating inflammation and its impact on organ recovery. The goal is to identify potential therapeutic strategies that could improve outcomes for older patients with sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk of or currently experiencing sepsis.
Not a fit: Patients who are younger or do not have a history of sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect older adults from severe organ damage during sepsis.
How similar studies have performed: Previous research has shown promising results in targeting inflammation in older adults, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Meng, Xianzhong — VA Eastern Colorado Health Care System
- Study coordinator: Meng, Xianzhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.