Reducing inflammation caused by radiation exposure
Modulation of chemokine signaling to mitigate radiation induced inflammation
This study is looking at a new way to help reduce inflammation caused by radiation exposure, which can be harmful to health, by testing a drug in mice that might block certain signals that attract immune cells, and it aims to find the best way to use this treatment for both younger and older animals.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11091451 on NIH RePORTER |
What this research studies
This research investigates how to reduce inflammation that occurs after radiation exposure, which can lead to serious health issues. It focuses on a specific signaling pathway involving chemokines, which are molecules that help control the movement of immune cells in the body. By using a mouse model, the researchers will test a drug that blocks a particular chemokine receptor to see if it can prevent both immediate and delayed inflammatory responses to radiation. The study aims to find the best dosage and timing for this treatment, and it will also explore its effectiveness in both young and older animals.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals who have been exposed to radiation or are undergoing radiation therapy for cancer treatment.
Not a fit: Patients who have not been exposed to radiation or do not require radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect patients from harmful inflammation after radiation therapy or exposure.
How similar studies have performed: Previous research has shown promise in using chemokine signaling modulation to reduce inflammation, indicating that this approach may be effective.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Saha, Subhrajit — University of Kansas Medical Center
- Study coordinator: Saha, Subhrajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.