Reducing inflammation caused by chemical exposure
Project 1: Reduction of Pro-Inflammatory Signaling
This study is looking at how certain chemicals can cause serious seizures and memory problems, and it's testing new treatments that might help reduce brain inflammation and protect against these issues, using rats to find the best ways to help people who experience these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10911235 on NIH RePORTER |
What this research studies
This research investigates how exposure to certain chemical agents can lead to severe seizures and long-term neurological issues, such as memory loss. Using a rat model, the project aims to test therapies that reduce inflammation in the brain, which may help prevent these adverse effects when given alongside standard treatments. The focus is on understanding how specific lipid mediators in the brain contribute to inflammation and exploring potential therapies that inhibit certain enzymes involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced acute exposure to organophosphate chemicals and are at risk for developing neurological complications.
Not a fit: Patients who have not been exposed to organophosphate chemicals or who do not exhibit neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that mitigate long-term neurological damage in individuals exposed to harmful chemicals.
How similar studies have performed: Previous research has shown that targeting inflammation can be beneficial in other neurological conditions, suggesting potential success for this approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Lein, Pamela J — University of California at Davis
- Study coordinator: Lein, Pamela J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.