Reducing inflammation and protecting brain cells in Alzheimer's disease
Official title: Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's disease
Funded at University of Virginia · NIH-10873859 · Data updated 2026-11-12
This study is looking at how a protein called MG53 might help reduce inflammation and protect brain cells in people with Alzheimer's disease, with the hope of finding new treatments to slow down the disease's progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $688,045 |
| NIH project number | 5R01AG072430-03 |
| Project ID | NIH-10873859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how a protein called MG53 can help reduce inflammation and protect brain cells in patients with Alzheimer's disease. The approach involves administering recombinant human MG53 to potentially slow down the progression of neurodegeneration by enhancing neuronal integrity and mitigating neuroinflammation. The study utilizes animal models to understand how MG53 can cross the blood-brain barrier and provide therapeutic benefits. If successful, this research could lead to new treatment options for individuals suffering from Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could provide a novel therapeutic approach to slow the progression of Alzheimer's disease and improve the quality of life for patients.
How similar studies have gone: Previous studies have shown promising results with similar approaches using MG53 in animal models, indicating potential for success in human applications.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Ma, Jianjie — University of Virginia
- Study coordinator: Ma, Jianjie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.