Reducing high insulin levels and insulin resistance in type 1 diabetes
Official title: Reducing Hyperinsulinemia and Insulin Resistance in Type 1 Diabetes Using Adjunctive Therapies
Funded at University of California, San Diego · NIH-11079590 · Data updated 2026-11-12
This study is looking at how combining different treatments can help people with type 1 diabetes lower their insulin levels and improve how their bodies respond to insulin, all while keeping an eye on heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $197,208 |
| NIH project number | 5K23DK134880-02 |
| Project ID | NIH-11079590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who experience high insulin levels and insulin resistance.
✕Less likely to help
Patients who do not have type 1 diabetes or those who are not experiencing issues with insulin levels may not benefit from this research.
What this research studies
This research investigates how combination therapies can help lower high insulin levels and improve insulin sensitivity in individuals with type 1 diabetes. By using a double-blind, placebo-controlled crossover approach, participants will receive both the new treatment and a placebo in alternating phases. The goal is to understand how these therapies can reduce the risk of cardiovascular disease, which is a significant concern for people with type 1 diabetes. Patients will be closely monitored to assess changes in insulin levels and tissue response.
Why it matters
Potential benefit: If successful, this research could lead to improved management of insulin levels and reduced cardiovascular risks for patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promise in using adjunctive therapies to manage insulin levels, indicating that this approach may be effective.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Boeder, Schafer Cale — University of California, San Diego
- Study coordinator: Boeder, Schafer Cale
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.