Reducing drug tolerance in tuberculosis treatment.
Minimizing in vivo Drug Tolerance induction in tuberculosis.
['FUNDING_OTHER'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10874608
This study is looking at how the immune system can help make tuberculosis treatments work better and stop the bacteria from becoming resistant, so it’s aimed at improving care for people with tuberculosis.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10874608 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune environment in the body affects the ability of tuberculosis bacteria to resist treatment. By manipulating host cells and their responses, the goal is to enhance the effectiveness of existing tuberculosis drugs and prevent the development of drug-resistant strains. The project utilizes advanced techniques, including CRISPR technology, to analyze how changes in immune pathways can improve drug efficacy. This approach aims to provide a more effective treatment strategy for tuberculosis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis who are undergoing treatment.
Not a fit: Patients with drug-resistant tuberculosis strains that are not responsive to current therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective tuberculosis treatments that reduce the risk of drug resistance.
How similar studies have performed: Other research has shown promise in using similar approaches to enhance drug efficacy and combat drug resistance in bacterial infections.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUSSELL, DAVID G — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: RUSSELL, DAVID G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.